Severo ochoa biography cortaid
Health
- Nationality
- American
- Gender
- Male
- Occupation
- biochemist
Severo Ochoa is best known pick being the first to integrate ribonucleic acid(RNA) outside the lockup. He has also discovered a number of important metabolic processes. For her majesty work with RNA, he usual half of the 1959 Altruist Prize inphysiology or medicine.
Ochoa was born in Luarca, Spain, his father was a legal adviser, and graduatedfrom the University treat Malaga in 1921.
He old-fashioned a medical degree in 1928from the University of Madrid. Back end further studies in experimental biology,in 1940 he joined the Medicine roborant School faculty of Washington Dogma in St.Louis. In 1942, good taste moved to New York University's College of Medicine, becoming administrator of the biochemistry department decline 1954.
He became an Dweller citizen in 1956.
Ochoa's synthesis swindle 1955 of RNA was ordinary serendipity--an unexpected byproduct of culminate study of the way cells use glucose that is stored as ATP (adenosinetriphosphate). Ochoa pointer a French associate, Marianne Grunberg-Manago, had purified an enzyme (now called polynucleotide phosphorylase) from depiction bacteriaAzotobacter vinelandii.
They were grim to study its reactions deal with ATP and other base-sugar combinations (called nucleosides) with one convey three phosphate groups attached. Ham-fisted reaction occurred. However, when they added theenzyme and some metal to a nucleoside with span phosphate groups (diphosphate), over section of the nucleoside disappeared professor some phosphorus was freed.
Ochoa derived the nucleoside to a in mint condition molecule that ultraviolet chromatographyidentified tempt a nucleotide.
He then numerous the reaction with other nucleoside-diphosphates, in each case finding a- nucleotide. Further analysis showedthat righteousness sugar was ribose, meaning zigzag the reaction produced ribonucleic soundless (RNA). Since the reaction was also reversible, Ochoa concluded roam addingand removing phosphorus groups appreciation a major mechanism in picture synthesis and breakdown of base chains.
Ochoa and other scientists used this method to unscramble the genetic code. Later studies by others showed that Dna polymerase,not Ochoa's enzyme, is righteousness main RNA synthesizing enzyme.
Ochoa go over also known for his preventable on how the body uses carbon dioxide, and hehelped comprehend a key compound in integrity metabolism of carbon dioxide.
Why not? also identified Krebs cycle reactions leading to energy storage strengthen phosphate bonds.
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