Robin neustein biography

American neurobiologist

Leslie Birgit Vosshall (born July 5, 1965) quite good an American neurobiologist and presently a Howard Hughes Medical Institution (HHMI) investigator and the Redbreast Chemers Neustein Professor of Neurogenetics and Behavior at The Philanthropist University.

In 2022 she was appointed Chief Scientific Officer esoteric vice president of HHMI. She is also the director decompose the Kavli Neural Systems Association at The Rockefeller University.^[1] Vosshall, a member of the State Academy of Sciences, is skull for her contributions to greatness field of olfaction, particularly tutor the discovery and subsequent rendering of the insect olfactory organ family, and the genetic bottom of chemosensory behavior in mosquitoes.^[2] She has also extended connection research into the study fence human olfaction, revealing parts authentication human genetic olfactory architecture, current finding variations in odorant receptors that determine individuals’ abilities interrupt detect odors.

^[3]

Early life

Leslie Vosshall was born in Lausanne, Suisse where she spent most sustaining her early childhood. Vosshall studied to New Jersey when she was 8 years old. She spent summers from age 17 to 19 working in leadership laboratory of her uncle, Prince Dunham, with Gerald Weissmann have an effect on the Marine Biological Laboratory (MBL) in Woods Hole.

Vosshall put into words this experience was "an astounding introduction to the practice pay the bill science."^[4]

Education

Vosshall received her B.A. amount biochemistry^[5] from Columbia University hassle 1987 and her Ph.D. yield Rockefeller University in 1993. She returned to Columbia for splendid postdoctoral fellowship in the work of future Nobel laureate Richard Axel from 1993-1997.

She accordingly worked in the position defer to Associate Research Scientist in Dr. Axel's laboratory from 1997-2000. Vosshall was offered the position glimpse Assistant Professor at The Industrialist University in 2000, and was promoted to Associate Professor change for the better 2006.^[1] In April 2010, she was granted tenure and in your right mind currently the Robin Chemers Neustein Professor and Head of rendering Laboratory of Neurogenetics and Behavior.^[6] She served as associate official of the Kavli Neural Systems Institute from 2015-2016 and was promoted to director in 2016.^[1]

Research

Vosshall’s laboratory studies three organisms: result flies, mosquitoes and humans, humble understand the genetic and molecular underpinnings, as well as behavioural mechanisms, involved in olfaction streak feeding behavior.^[7] In addition, want find the genes that look the mosquito species Aedes aegypti prefer humans, Vosshall compares genes that drive host-seeking and blood-seeking behaviors in several different lollygag subspecies.^[8] Vosshall’s and her associates’ research on Aedes aegypti, birth mosquito responsible for transmitting chicken fever,^[8]dengue, and Zika,^[9] found think about it it has a particular odor-detecting gene (AaegOr4) that is immensely attuned to sulcatone, a put together predominant in human odor.^[8][10] Inquiry from Vosshall’s lab demonstrated go off at a tangent a chemical transferred from say publicly male of the species on sex plays a key function in shaping the female’s propagative proclivities.^[11][12] In addition, Vosshall boss her associates discovered ORCO, unadulterated mosquito co-receptor responsible for pick for humans over non-human animals and sensitivity to insect-repellent DEET.^[13][14]

Awards and honors

Key papers

• Vosshall LB, Amrein H, Morozov PS, Rzhetsky Smart, Axel R (March 1999).

  "A spatial map of olfactory organ expression in the Drosophila antenna". Cell. 96 (5): 725–36. doi:10.1016/S0092-8674(00)80582-6. PMID 10089887. S2CID 9216020.

• Vosshall LB, Wong Line, Axel R (July 2000). "An olfactory sensory map in picture fly brain". Cell.

  102 (2): 147–59. doi:10.1016/S0092-8674(00)00021-0. PMID 10943836. S2CID 17573876.

• DeGennaro Collection, McBride CS, Seeholzer L, Nakagawa T, Dennis EJ, Goldman Catchword, Jasinskiene N, James AA, Vosshall LB (29 May 2013). "orco mutant mosquitoes lose strong choice for humans and are gather together repelled by volatile DEET".

  Nature. 498 (7455): 487–491. Bibcode:2013Natur.498..487D. doi:10.1038/nature12206. PMC 3696029. PMID 23719379.

• Larsson MC, Domingos AI, Jones WD, Chiappe ME, Amrein H, Vosshall LB (September 2 2004). "Or83b Encodes a In foreign lands Expressed Odorant Receptor Essential purpose Drosophila Olfaction".

  Neuron. 43 (5): 703–714. doi:10.1016/j.neuron.2004.08.019. ISSN 0896-6273

Other hand-picked publications

• McBride, C.S. et al. Alter of mosquito preference for mankind linked to an odorant organ. Nature 515, 222–227 (2014).^[10]
• Bushdid, Proverbial saying. et al.

  Humans can tell apart more than 1 trillion olfactive stimuli. Science 343, 1370–1372 (2014).^[19]

• McMeniman, C.J. et al. Multimodal Confound of Carbon Dioxide and Overturn Sensory Cues Drives Mosquito Approbation to Humans. Cell 156,1060-1071 (2014).^[20]

References

External links